無創產前基因檢測

無創產前檢測是一項高度準確的無創產前篩查技術,與傳統入侵性檢驗方法不同,傳統入侵性如絨毛活檢、羊膜穿刺等檢查,存在流產風險。懷孕期間,寶寶的DNA會傳到母親的血液內,而無創產前篩查技術,只需抽取少量孕婦血液,便可檢查出寶寶是否有潛在的疾病風險。此技術無流產風險,而且準確性高於99%,大大減少了誤診的可能性。而目前有敏兒安T21express™及時代T21-7週兩種。





透過無創產檢,準媽媽可以取得哪些資料?

產前篩檢可測試到嬰兒染色體的特定異常情況。
人體共有 23 對 (每對兩條,合共 46 條) 染色體。
前 22 對染色體依次命名為 1 至 22 號染色體,最後一對染色體會決定胎兒性別。女性有兩條 X 染色體,男性則會有一條 X 和 一條 Y 染色體。
任何染色體的多餘或缺失都會引起健康及發育問題。


哪類人士適合無創產前基因檢測 ? 

不論任何年齡或種族,任何懷孕週期已達7週的孕婦均可接受無創產前篩查



Y-Chromosome DNA Test

In the 1970’s scientists discovered that fetal DNA passes through the placenta and enters the maternal blood circulatory system in the form of fetal metabolites or fetal DNA fragments. Experts point out that, the longer the fetus stays in the womb, the more concentrated the fetal DNA fragments will be in the maternal blood. In addition, the faster the diffusion process, the more fetal DNA fragments will be found in the maternal blood.
To summarize, a longer gestation period and faster diffusion process, results in more fetal DNA fragments in the maternal circulatory system. Nowadays, fetal sex can be determined through the application of advanced maternal blood DNA testing technology as early as 5 gestation weeks. The test involves isolating the fetal DNA fragments from the maternal serum, and then extracting and amplifying them. Once millions or possibly billions of copies have been made, the male DNA will be tested with the Sex-determining Region Y (SRY) markers.
In males, Y DNA is the genetic material that is inherited from the father only, which is crucial material for the fetus to develop as a male. Since Y DNA is inherited from the father and then passed on to the son, it can be used in paternity confirmation by simple comparison.

Test Details

Code Test Sample format TAT (working day)
Yi-R Yi Y-chromosome maternal serum test 10mL Medtimes CELL-Free BCT x 1 1 Enquiry
YCHR5 Y-chromosome maternal serum test (5 weeks) 10mL CELL-Free BCT x 1 1
YCHR6 Y-chromosome maternal serum test (6 weeks) 10mL CELL-Free BCT x 1 1
YCHR Y-chromosome maternal serum test (7 weeks +) 10mL CELL-Free BCT x 1 1

Test Features

1. No Fasting is required

2. Non-invasive, inflicting minimal harm to the fetus

3. Unaffected by medication or body condition

4. High sensitivity, a tiny amount of fetal Y-DNA can be detected precisely

5. High accuracy, >99.99%

Paternity Testing

Parentage tests are used to determine whether two individuals have a biological parent-child relationship. It is done by collecting and analyzing DNA from the alleged parent and child. The child’s profile is compared with the profile of the mother and alleged father to confirm that he or she has inherited DNA from the alleged father. Statistical analysis is then performed to calculate the Paternity Index, which determines the probability of paternity. We are able to do paternity testing with or without samples from the mother, as well as maternity testing, grandparentage testing, sibling testing, and prenatal testing. Please contact us directly for further information.

Paternity Test (alleged father and fetus)

Prenatal parentage testing is a different type of parentage testing in which the father-child relationship can be identify before the child is born. The test allows the earliest possible confirmation of father-child relationship. This is particularly useful for cases where the genuine identity of the biological father must be known before childbirth.

Usually, methods of sample collection for prenatal parentage testing include Chorionic Villus Sampling or Amniocentesis. These methods are not only invasive, but cannot be conducted until at least 10 weeks into the pregnancy.
However, at Medtimes, we are able to perform the parentage test by using the blood of the mother (maternal blood). Currently, this is the only non-invasion prenatal paternity testing method, and can be performed after the 7th week of pregnancy.

Prenatal Autosomal Maternal Serum Paternity Test

Unlike Y-Chromosomal paternity testing, Autosomal Maternal Serum Paternity Test requires extremely advanced techniques for the separation and differentiation of fetal cf-DNAs. In normal circumstances, fetal cf-DNAs will be existing as low as 1% in the maternal plasma, and leading to the detection of fetal cf-DNAs difficult. In addition, due to the fact that the female baby's DNA signal will be significantly masked by maternal DNA, this makes the analyzing and extracting the fetal DNA further problematic.


Prenatal Non-invasive‧Gestational Week: 7 weeks

Usually, methods of sample collection for prenatal parentage testing include Chorionic Villus Sampling or Amniocentesis. These methods are not only invasive, but cannot be conducted until at least 10 weeks into the pregnancy. However, at Medtimes, we are able to perform the parentage test by using the blood of the mother (maternal blood). Currently, this is the only non-invasion prenatal paternity testing method, and can be performed after the 7th week of pregnancy.



Prenatal Test Details

Code Test Sample format TAT (Working day)
YPAT Y-chromosome Maternal Serum Paternity Test Maternal blood 8.5mL Cell-Free DNA BCT x 2
7
1 alleged father
Father, Buccal Swab x 2 or
3 mL EDTA Blood x 1
XYPAT Maternal Serum Paternity Test Maternal blood 8.5mL Cell-Free DNA BCT x 2 8-12
1 alleged father Buccal Swab x 2 or
3 mL EDTA Blood x 1


Postnatal Test Details

Code Test Sample format TAT (Working day)
PATLAB
Paternity Test
(Legal Use, AABB*)
Child Buccal Swab x 3 14
1 alleged father/mother Buccal Swab x 3
PATL Paternity Test
(Legal Use)
Child Buccal Swab x 3 or
3 mL EDTA Blood x 1
14
1 alleged father/mother Buccal Swab x 3 or
3 mL EDTA Blood x 1
PATN Paternity
(Non-Legal Use)
Child Buccal Swab x 3 or
3 mL EDTA Blood x 1
7
1 alleged father/mother Buccal Swab x 3 or
3 mL EDTA Blood x 1


Note

1. Please do not eat or drink for at least 1 hour before the sampling.

2. If a blood transfusion was received in the past 3 months, or an allogeneic hematopoietic progenitor cell transplantation (bone marrow transplantation) was received at any time, false results can be obtained. For enquiries, please contact Customer Service at 3585 8533.



 

*Hong Kong Medtimes Medical Group have been awarded the ISO9001 accreditation, and their Medtimes Molecular Laboratory has been awarded the AABB accreditation in relationship testing, this is the first in HK, and the only one for the time being.
The ISO 9001 accreditation marks that the management system of Medtimes Molecular Laboratory reached international level. And the AABB accreditation further marks that the equipments and technical skills of Medtimes Molecular Laboratory have reached international highest level of recognition.
AABB developed high procedure standards and quality control for accredited laboratories, their certification represents the highest international standards and authority.



 Enquiries & Appointments: 3585 8533



What is relationship testing?

Relationship testing is done to determine various types of biological relationships.
For example, a grandparentage test can be conducted to determine if a biological relationship exists between the alleged grandparent and the child, in cases where the alleged father is not available to do the test. Other types of relationship tested include twins, sibling, aunt/uncle, cousin, and nephew/niece.

How is it done?

To carry out the test, all we need are genomic DNA from the two test subjects. Genomic DNA can be obtained from buccal swab and whole blood. We then compare the lengths of specific repeated DNA sequences in the chromosomes of the two test subjects. From there, we will be able to accurately determine the existence of a biological relationship between them.

Test method and theory

Short Tandem Repeat (STR) DNA typing is used to conduct the relationship testing. STRs are short repeated DNA sequences found in the chromosome of every individual. An individual inherits one copy of an STR from each parent, and unrelated people almost certainly have different repeat units. Thus, STR is an effective marker of biological relationships.

Code Test Sample Format TAT (Working day)
PATLAB
Relationship Test
(Legal Use, AABB*)
Buccal Swab x 2 or 3ml EDTA Blood x 1 14
PATL Relationship Test
(Legal Use)
Buccal Swab x 2 or 3ml EDTA Blood x 1 14
PATN Relationship Test
(Non-Legal Use)
Buccal Swab x 2 or 3ml EDTA Blood x 1 7


Note

1. Please do not eat or drink for at least 1 hour before the sampling.

2. If a blood transfusion was received in the past 3 months, or an allogeneic hematopoietic progenitor cell transplantation (bone marrow transplantation) was received at any time, false results can be obtained. For enquiries, please contact Customer Service at 3585 8533.



 

*Hong Kong Medtimes Medical Group have been awarded the ISO9001 accreditation, and their Medtimes Molecular Laboratory has been awarded the AABB accreditation in relationship testing, this is the first in HK, and the only one for the time being.
The ISO 9001 accreditation marks that the management system of Medtimes Molecular Laboratory reached international level. And the AABB accreditation further marks that the equipments and technical skills of Medtimes Molecular Laboratory have reached international highest level of recognition.
AABB developed high procedure standards and quality control for accredited laboratories, their certification represents the highest international standards and authority.



 Enquiries & Appointments: 3585 8533



Gynecology

Code Test Sample format TAT (working day)
CTDNA Chlamydia trachomatis DNA HVS/ LVS Swab x 1 1
NGDNA Neisseria Gonorrhoeae DNA 1
MGDNA Mycoplasma Genitalium DNA 1
UUDNA Ureaplasma urealyticum DNA 1
TVDNA Trichomonas vaginalis (TV) DNA 1
CADNA Candida albicans (CA) DNA 1
GVDNA Gardnerella vaginalis DNA 1
SA B DNA Group B Strep. (S. agalactiae) DNA 1
TOXDNA Toxoplasma gondii DNA 3mL EDTA Blood x 1 or Amniotic fluid 1
HSVDNA Herpes Simplex Virus (HSV) 1&2 DNA Lesion Swab x 1 1
MHDNA Mycoplasma Hominis DNA HVS/ LVS Swab x 1 1
ZIKA ZIKA Virus RNA Test 6mL EDTA Blood x 1 2

Pediatrics

Code Test Sample format TAT (working day)
CMVDNA CMVDNA 6mL EDTA Blood x 1 1
RUBDNA Rubella Virus DNA Nasopharyngeal or throat Swab x 1 1
VZVDNA Varicella - Zoster Virus DNA Lesion Swab x 1 1

Hepatitis

Code Test Sample format TAT (working day)
HBVDNA Hepatitis B Virus DNA (Quantitative) 3mL EDTA Blood x 1 1
HBVDNAQL Hepatitis B Virus DNA (Qualitative) 6mL EDTA Blood x 1 3
HBVHSDNA HBV, DNA Hight Sensitivity Viral Load, Quantitative 3
HBVMDR HBV Multi-drug Resistance Genotyping (LAM + TEL + ADE + ETV + TDF) 3
HBVYMDD HBV Lamivudine Resistance Genotyping-YMDD 3
HCVGENO HCV Genotyping 3
HCVRNA HCV - RNA (Quantitative) 3
HCVRNA-QL HCV - RNA (Qualitative) 3

Epstein–Barr virus

Code Test Sample format TAT (working day)
EBVDNA EBV DNA (Quantitative) Nasopharyngeal Swab x 1 or
6mL EDTA Blood x 1
2
EBVDNA-QL EBV DNA (Qualitative) 2

HPV

Code Test Sample format TAT (working day)
HPV2 HPV Genotyping for 16, 18 Thinprep or
Swab x 1 or
Tissue
1
HPV4 HPV Genotyping for 6,11,16,18 1
HPV13 HPV Genotyping Test (13 genotypes) 3
HPV29 HPV Genotyping Test (29 genotypes) 3
HPV37 HPV Genotyping Test (37 genotypes) 3



 Enquiries & Appointments: 3585 8533



MYH7 Cardiac Genetic Test

Primary cardiomyopathy is an inherited heart muscle disease, which increases the contractility and cardiac output in filling and pumping blood into the heart, eventually leading to irreversible heart dysfunction. This disease affects all ages and races, also associates with heart failure, arrhythmia and sudden cardiac death. The common type hypertrophic cardiomyopathy is the enlargement of heart muscle without any noticeable pathological reason, and it is known as the main cause of sudden cardiac death in young athletes.

Medtimes in-house developed MYH7 Cardiac Genetic Test targets MYH7 gene that relates to familial hypertrophic cardiomyopathy, primary dilated cardiomyopathy, myosin storage myopathy and so on. This test helps to identify carriers before the on-set of the disease, allows affected individual to recognize the potential risk and perform preventive actions according to the instructions of cardiologist.

測試編碼 測試名稱 樣本要求 測試需時 (工作天)
MYH7 MYH7 Cardiac Genetic Test Buccal Swab x 2 5
Buy
$1200

隱性基因疾病

隱性基因疾病是由基因變異所引致。
每組基因都由兩條染色體組成,一條來自父親,另一條來自母親。
當父母同時擁有變異基因並遺傳到下一代時,子女便有機會成為病患者。


部份隱性基因遺傳病會出現以下情況



只有有限或無法治療

有些疾病目前尚未有有效的治療方法



導致壽命縮短

患者平均壽命減少,生活質素受影響,包括慢性症狀或併發症



智力有機會愛影響

智力殘疾的風險,程度各有不同



需要早期控制幫助改善病情

多數人接受標準治療後,可有效控制病情



隱性遺傳病基因檢測

隱性遺傳病基因檢測可以助您和伴侶檢測到遺傳病的攜帶者基因,分析下一代患上遺傳病的風險,及早為生育做好準備。



適合接受檢測人士



早期孕婦



準備結婚人士



Test Details

測試代碼 Test Name Types of illness Sample Format TAT (Working Days) Price
NJ20 Mygenia Carrier Risk Assessment Test - Focus Panel 20 6mL EDTA Blood x 1 or Buccal Swab x 6 2-4 Weeks
$9000


 Enquiry & Booking: 3585 8533



What is Metabolic Disorders

Babies with metabolic disorders lack certain enzymes to maintain the normal metabolic function, causing the build-up of toxic substances or deficiency of critical nutrients.
The onset of some metabolic disorders may by delayed by several years after the baby is born with no obvious symptoms, making it difficult for parents to take action and may cause irreversible damage to the children.

Some affected children appear normal without obvious symptoms.
The found symptoms like loss of appetite, vomiting, acratia, developmental retardation and lethargy may be misdiagnosed.
The health condition of these babies may become worse in a short time or the IQ will be dropped by 1 point per week, and even with lifelong disabilities and have risk of death.


Early Detection Allows for Timely Intervention

Most metabolic disorders be controlled by introducing appropriate diet restriction and medical treatment. The outcome will become better through early diagnosis. For example, lactose intolerance can be treated by restricting dairy product intakes. In contrast, some diseases like PKU, Isovaleric aciduria and Biotinidase deficiency would require strict dietary control or specific supplements intake in the treatment.


What is Metabolic Diseases Screening

Metabolic disorders cannot be completely treated and screened through antenatal check-up.
Metabolic Diseases Screening helps parents to detect harmful or potentially fatal metabolic diseases at an earlier stage.


Comprehensive Metabolic Diseases Screening

The sample can be easily collected by placing a filter paper in urine. This collection is non-invasive and causes no discomfort to your children.



Test Details

Product Code Test Sample Format TAT (Working Day) Price
META106 Comprehensive Metabolic Diseases Screening Urine Sample 10 - 14
$2400




$2400

What is Cancer?

Cancer is a disease of the body's cells. Our bodies are always making new cells: so we can grow, to replace worn-out cells, or to heal damaged cells after an injury. This process is controlled by certain genes. All cancers are caused by damage to these genes. This damage usually happens during our lifetime, although a small number of people inherit a damaged gene from a parent.
Normally, cells grow and multiply in an orderly way. However, damaged genes can cause them to behave abnormally. They may grow into a lump called a tumour. These lumps can be benign (not cancerous) or malignant (cancerous).
Benign lumps do not spread to other parts of the body.


A malignant lump (more commonly called a malignant tumour) is made up of cancer cells. When it first develops, this malignant tumour is confined to its original site. If these cells are not treated they may spread into surrounding tissue and to other parts of the body.
When these cells reach a new site they may continue to grow and form another tumour at that site. This is called a secondary cancer or metastasis.

What Causes Cancer?

The exact cause of many cancers is not yet known, however most cancers are attributed to our lifestyle habits or substances in the environment that affect our bodies.

• The major causes of cancer are thought to include smoking, sun exposure, poor diet, chemicals and asbestos. Cancer causing substances are called carcinogens.
• In certain cases, viruses prompt the development of cancer. For example, the sexually-transmitted disease, Human Papilloma Virus (HPV), is cited as causing of 70% of cervical cancer cases in women.

Is Cancer Infectious?

No. Cancer is not an infectious disease. It cannot be passed on to friends or relatives, or people you come in contact with.

Is Cancer Genetic?

People who have a family history of some cancers, such as breast and colorectal cancer, may have a higher risk of developing that cancer. In a very small number of families, a change in the gene that controls cell growth is passed on from one generation to the next. Not all family members experience this change; although those individuals who do may have a higher chance of developing cancer.

How Does Cancer Spread?

For a cancer to grow bigger than the head of a pin, it must grow its own blood vessels. This is called angiogenesis. Sometimes cells move away from the original (primary) cancer, either by the local tissue fluid channels (lymphatics) or in the blood stream, and invade other organs. When these cells reach a new site, they may continue to grow and form another tumour at that site. This is called a secondary cancer or metastasis.


 
Mygenia ONE

Why do we need cancer risk assessment?

Cancer has always ranked the number one killer worldwide and everyone knows that. However, not everyone knows that cancer can be predicted and prevented. Identifying the inheritance of cancer genes opens up chances for early preventive measures.
 
Coverage - Screening more than 2,700 disease-related genes
These genes have been proven to be associated with more than 1,000 diseases, including a variety of cancers and heart disease.

Precision cancer tests:
Breast & Ovarian, Colorectal, Gastric, Kidney, Pancreatic, Prostate, Paraganglimoa, Neuroblastoma, Retinoblastoma, Skin, Endocrine,
Head & Neck

Heart conditions:
Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Long QT syndrome, Short QT syndrome,
Wolff–Parkinson–White syndrome
Hereditary risk assessments:
Spinal muscular atrophy, Thalassemia, Ankylosing spondylitis

鼻咽癌

位於頭顱中間,鼻腔盡頭,喉嚨上端「隱形」空間裡的惡性腫瘤,屬頭頸部癌症。


鼻咽癌常見病徵

一般早期鼻咽癌難以被肉眼察覺,患者也不會出現明顯病徵,往往到了流鼻血、頭痛和耳鳴次數增加才去求醫,甚至到了中晚期才發現病情,錯失黃金治療時間。


高危因素

‧ 居住在南中國和東南亞地區人士 ‧ 較多接觸其他致癌物
‧ 40歲以上 ‧ 家族遺傳
‧ 有吸煙習慣 ‧ 感染EB病毒
‧ 較多食用鹽醃食品 ‧ 較多接觸甲醛或化學品

如出現任何上述因素,須提高警覺及諮詢醫護人員,因為每發現多一項高危因素,患癌風險會顯著提高。
在鼻咽癌達到晚期前,許多患者沒有任何病徵。在沒有進行早期篩查的患者中,大約80%在初診時已患上晚期鼻姻癌。

由於目前尚無預防鼻咽癌的疫苗,早期癌症篩查是可以大大提高成功治療機會的一個有效方法。


早期鼻咽癌篩查

Prophecy是一項適用於無症狀人士的鼻咽癌早期篩查測試。
潛在的鼻咽癌患者的癌細胞會將DNA釋放到血液中。Prophecy應用了最新的基因檢測技術來檢測血液中與鼻咽癌相關的人類和EB病毒DNA特徵。


測試詳情

測試名稱 樣本要求 測試需時 (工作天) 檢測費用
Prophecy 早期鼻咽癌篩查 8.5ml Cell-Free 採血管 x 2 4 - 10
$3000


 查詢及預約: 3585 8533



Buy
$3000

麼是地中海貧血?

地中海貧血,簡稱地貧,是一種遺傳性血液疾病。地貧患者的身體會產生異常大小或型狀的血紅蛋白/血色素/血紅素,以致無法提供足夠氧氣到身體所有細胞,異常導致大量紅血球破壞,造成貧血。 

地中海貧血的類型

血紅蛋白由甲型(α)蛋白鏈乙型(β)蛋白鏈組成。
每一個人會擁有兩組血紅蛋白基因;一組來自父親,另一組來自母親。

地貧大致可分為甲型(α)和乙型(β)兩類,
而按照嚴重程度再分為輕型重型

輕型地中海貧血症主要遺傳了父親或母親的異常基因,
一般都沒有特別明顯病徵。
而重型地中海貧血症則遺傳了父母雙方的異常基因,會嚴重貧血。


地中海貧血來自遺傳



夫婦都沒有地貧基因
下一代不可能有地貧基因





夫婦任何一方帶有地貧基因
子女遺傳地貧基因機會為50%而成為地貧基因攜帶者




夫婦二人都帶有地貧基因
子女有25%機會是健康的
50%機會患上輕型地貧
25%機會患上重型地貧


地中海貧血基因檢測

現時,甲型(α)和乙型(β)地貧基因可以靠驗血檢測出來。一般測試會進行血紅蛋白基因分析,檢測有否異常狀況。
時代基因檢測中心研發的地貧測試可直接進行基因測試,驗出異常基因。

測試代碼 測試名稱 樣本要求 測試需時 (工作天) 檢測費用
HBADNA 地中海貧血基因檢測A 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,200
HBBDNA 地中海貧血基因檢測B 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,200
HBDNA 地中海貧血基因檢測A&B 3mL EDTA採血管 x 1 或 口腔拭子 x 2 5 $3,800


基因是生命的基本因子。

人的成長,智商,運動,藝術,生老病死等一切生命現象都與基因有著密切的關係。天賦基因是先天遺傳,伴隨終生,決定人的個性、特長、能力的遺傳密碼。


天賦基因測試 助父母破解孩子的天賦基因遺傳密碼

父母是孩子的啟蒙對象,合適的教育方法才能讓孩子學習得宜,走得更輕鬆。而錯誤的方法,只會埋沒孩子的才能,錯失孩子發揮所長的機會。


因材施教 成就夢想

每個孩子心中都有一個夢想。助孩子實現夢想,父母需了解他們的天賦與潛力,才能有效地因材施教;孩子也可以盡情發揮所長,塑造無限的可能。更進一步奔向目標、實現夢想。  

健康成長 拒絕煩惱

通過基因檢測發現成長風險基因,了解孩子身體狀況的可能性,為家長及早預測孩子的成長風險,針對性地採取預防措施,幫助孩子健康成長。 


天賦基因對孩子的好處?


 認識自己孩子的天賦特質,重點培育,發揮所長

 及早預防及防止身體各種成長的風險

 清楚自己孩子心智發展風險特質,加強親子關係

 為孩子制定及選擇適合的活動,更適當地善用資源及時間


檢測流程

收集樣本 → 樣本檢測 → 基因分析 → 基因報告


*只需收集小量唾液樣本進行分析,採集員會為客戶採集樣本。
*樣本會在24小時內運抵時代基因中心進行檢測,確保樣本的活躍性。
*時代基因科研團隊利用先進基因分析技術及龐大的基因數據庫分析您的基因組合
*專業的基因檢測報告最快可以在4周內完成
*適合0至12歲兒童


測試詳情

測試代碼 測試名稱 樣本要求 測試需時 (工作天) 檢測費用
TALENT14S 兒童天賦基因檢測 口腔拭子 x 2 24
$3800


Buy
$3800
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